CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice

CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice.

Pancreatic cancer, one of the deadliest human malignancies, is associated with oncogenic Kras and is most commonly preceded by precursor lesions known as pancreatic intraepithelial neoplasias (PanIN). PanIN formation is accompanied by the establishment of an immunotolerant microenvironment. However, the immune contribution to the initiation of pancreatic cancer is currently poorly understood. H...

Comparison of CD4+ and CD8+ T- lymphocyte in Helicobacter pylori-negative functional dyspepsia

CD4+ T-lymphocyte alterations in trauma patients

colleagues reporting an association between persistent lymphopaenia and increasin g mortality in trauma patients [1]. We would like to provide some additional data obtained in a similar cohort of patients. In parallel with a study recently published in Critical Care in which mHLA-DR expression was assessed [2], we evaluated the CD4 + lymphocyte count and the percentage of CD4 + CD25 + regulator...

B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation

Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...

Mushroom Ganoderma lucidum Prevents Colitis-Associated Carcinogenesis in Mice

BACKGROUND Epidemiological studies suggest that mushroom intake is inversely correlated with gastric, gastrointestinal and breast cancers. We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma lucidum (GLT). The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice. METHO...